|
Symbol Name ID |
Ctla4
cytotoxic T-lymphocyte-associated protein 4 MGI:88556 |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased circulating IgA level |
Increased circulating IgA level |
Increased circulating IgG level |
Increased circulating IgM level |
Decreased circulating antibody level |
Paraproteinemia |
Secretory IgA deficiency |
Retinal hemorrhage |
Diffuse alveolar hemorrhage |
Localized pulmonary hemorrhage |
Anemia |
Hemolytic anemia |
Autoimmune hemolytic anemia |
Eosinophilia |
Increased T cell count |
Leukopenia |
Abnormal lymphocyte morphology |
Granulomatosis |
Hemophagocytosis |
Acute myeloid leukemia |
Superficial thrombophlebitis |
Thrombocytopenia |
Lymphoma |
Multiple myeloma |
Splenomegaly |
Hepatosplenomegaly |
| Disease(s) Associated with CTLA4 | ||||||||||||||||||||||||||
| acute myeloid leukemia | ||||||||||||||||||||||||||
| autoimmune hemolytic anemia | ||||||||||||||||||||||||||
| Behcet's disease | ||||||||||||||||||||||||||
| graft-versus-host disease | ||||||||||||||||||||||||||
| granulomatosis with polyangiitis | ||||||||||||||||||||||||||
| immunoglobulin alpha deficiency | ||||||||||||||||||||||||||
| multiple myeloma | ||||||||||||||||||||||||||
| non-Hodgkin lymphoma | ||||||||||||||||||||||||||
| primary biliary cholangitis | ||||||||||||||||||||||||||
| sarcoidosis | ||||||||||||||||||||||||||
| systemic lupus erythematosus |
| Mouse Phenotypes | increased T cell proliferation |
abnormal thymus morphology |
enlarged spleen |
spleen hyperplasia |
abnormal T cell differentiation |
increased double-negative T cell number |
decreased double-positive T cell number |
increased effector memory CD4-positive, alpha-beta T cell number |
increased effector memory CD8-positive, alpha-beta T cell number |
decreased CD8-positive, naive alpha-beta T cell number |
increased regulatory T cell number |
decreased T cell number |
increased T cell number |
abnormal T cell morphology |
abnormal splenic cell ratio |
abnormal immunoglobulin level |
increased IgE level |
increased IgG level |
abnormal T cell physiology |
abnormal regulatory T cell physiology |
|
| Availability | Mouse Genotype | ||||||||||||||||||||
| Ctla4m1Btlr/Ctla4m1Btlr | |||||||||||||||||||||
| Ctla4tm1All/Ctla4tm1All | |||||||||||||||||||||
| Ctla4tm1Shr/Ctla4tm1Shr | |||||||||||||||||||||
| Ctla4tm1Saka/Ctla4tm1Saka Foxp3tm1(cre)Saka/Y (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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